EpiTrace is an AI-driven platform that aggregates and analyzes vast datasets including ancient DNA, historical epidemiological records, modern genomic data, and environmental factors to re-evaluate the origins of diseases and predict future health threats. It solves the problem of fragmented and often misunderstood disease etiologies by providing a comprehensive, data-driven approach to understanding how diseases emerge, spread, and evolve, drawing lessons from both past pandemics and contemporary re-evaluations of conditions like myocardial infarction. The platform helps researchers and public health officials identify novel connections, understand long-term disease patterns, and anticipate potential outbreaks.